The SM.83s were used by the Ala Littoria S.A. Linee Atlantiche and Linee Aeree Transcontinentali Italiane (L.A.T.I.) to fly to South America from 1938 - 1939.
The SM.83A and SM.83T were used by the Ala Littoria.
In 1940 ten of the SM.83s were used by the Commando Servizi Aerei Speciali to deliver communications to Italian colonies, South America, and Germany.
Eight of the SM.83s were assigned to the 615a Squadriglia "T" based at Guidonia and used as military transports.